Discovered new human cell structure

A new structure in human cells has been discovered by researchers at Karolinska Institutet in Sweden in collaboration with colleagues in the UK.

The structure is a new type of protein complex that the cell uses to attach to its surroundings and proves to play a key part in cell division. 

The cells in a tissue are surrounded by a net-like structure called the extracellular matrix to attach itself to the matrix the cells have receptor molecules on their surfaces, which control the assembly of large protein complexes inside them.
These so-called adhesion complexes connect the outside to the cell interior and also signal to the cell about its immediate environment, which affects its properties and behaviour.
Researchers at Karolinska Institute have now discovered a new type of adhesion complex with a unique molecular composition that sets it apart from those already known about. The discovery has been made in collaboration with researchers in the UK.
The present discovered adhesion complex can provide answers to an as-yet unanswered question  how the cell can remain attached to the matrix during cell division. The previously known adhesion complexes dissolve during the process to allow the cell to divide. But not this new type.
The newly discovered structures control the ability of daughter cells to occupy the right place after cell division. This memory function was interrupted when the researchers blocked the adhesion complex.
The study was done on human cell lines mainly using confocal microscopy and mass spectrometry. Further research is now needed to examine the new adhesion complex in living organisms.
The researchers call the newly discovered cell structure 'reticular adhesions' to reflect their net-like form.
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